Genome-wide association study reveals two new risk loci for bipolar disorder.
Identifieur interne : 003906 ( Main/Exploration ); précédent : 003905; suivant : 003907Genome-wide association study reveals two new risk loci for bipolar disorder.
Auteurs : Thomas W. Mühleisen ; Markus Leber ; Thomas G. Schulze ; Jana Strohmaier [Allemagne] ; Franziska Degenhardt [Allemagne] ; Jens Treutlein [Allemagne] ; Manuel Mattheisen [Allemagne] ; Andreas J. Forstner [Allemagne] ; Johannes Schumacher [Allemagne] ; René Breuer [Allemagne] ; Sandra Meier ; Stefan Herms [Suisse] ; Per Hoffmann [Suisse] ; André Lacour [Allemagne] ; Stephanie H. Witt [Allemagne] ; Andreas Reif [Allemagne] ; Bertram Müller-Myhsok [Royaume-Uni] ; Susanne Lucae [Allemagne] ; Wolfgang Maier [Allemagne] ; Markus Schwarz [Allemagne] ; Helmut Vedder [Allemagne] ; Jutta Kammerer-Ciernioch [Allemagne] ; Andrea Pfennig [Allemagne] ; Michael Bauer [Allemagne] ; Martin Hautzinger [Allemagne] ; Susanne Moebus [Allemagne] ; Lutz Priebe [Allemagne] ; Piotr M. Czerski [Pologne] ; Joanna Hauser [Pologne] ; Jolanta Lissowska [Pologne] ; Neonila Szeszenia-Dabrowska [Pologne] ; Paul Brennan [France] ; James D. Mckay [France] ; Adam Wright [Australie] ; Philip B. Mitchell [Australie] ; Janice M. Fullerton [Australie] ; Peter R. Schofield [Australie] ; Grant W. Montgomery [Australie] ; Sarah E. Medland [Australie] ; Scott D. Gordon [Australie] ; Nicholas G. Martin [Australie] ; Valery Krasnow [Russie] ; Alexander Chuchalin [Russie] ; Gulja Babadjanova [Russie] ; Galina Pantelejeva [Russie] ; Lilia I. Abramova [Russie] ; Alexander S. Tiganov [Russie] ; Alexey Polonikov [Russie] ; Elza Khusnutdinova [Russie] ; Martin Alda [Allemagne] ; Paul Grof [Canada] ; Guy A. Rouleau [Canada] ; Gustavo Turecki [Canada] ; Catherine Laprise [Canada] ; Fabio Rivas [Espagne] ; Fermin Mayoral [Espagne] ; Manolis Kogevinas [Espagne] ; Maria Grigoroiu-Serbanescu [Roumanie] ; Peter Propping [Allemagne] ; Tim Becker [Allemagne] ; Marcella Rietschel ; Markus M. Nöthen ; Sven CichonSource :
- Nature communications [ 2041-1723 ] ; 2014.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Adenylyl Cyclases.
- genetics : Bipolar Disorder, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide.
- methods : Genome-Wide Association Study.
- Female, Humans, Male.
Abstract
Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD.
DOI: 10.1038/ncomms4339
PubMed: 24618891
Affiliations:
- Allemagne, Australie, Canada, Espagne, France, Pologne, Roumanie, Royaume-Uni, Russie, Suisse
- Bade-Wurtemberg, Bavière, Berlin, Catalogne, District de Basse-Franconie, District de Cologne, District de Dresde, District de Haute-Bavière, District de Karlsruhe, District de Tübingen, District fédéral central, Ontario, Québec, Rhénanie-du-Nord-Westphalie, Saxe (Land)
- Barcelone, Berlin, Bonn, Dresde, Mannheim, Montréal, Moscou, Munich, Toronto, Tübingen, Wurtzbourg
- Université McGill, Université de Toronto
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Mühleisen</name><affiliation><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, D-52425 Jülich, Germany [4].</nlm:affiliation><wicri:noCountry code="subField">Germany [4]</wicri:noCountry></affiliation></author><author><name sortKey="Leber, Markus" sort="Leber, Markus" uniqKey="Leber M" first="Markus" last="Leber">Markus Leber</name><affiliation><nlm:affiliation>1] Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany [2] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, D-53175 Bonn, Germany [3].</nlm:affiliation><wicri:noCountry code="subField">Germany [3]</wicri:noCountry></affiliation></author><author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G" last="Schulze">Thomas G. Schulze</name><affiliation><nlm:affiliation>1] Department of Psychiatry and Psychotherapy, University of Go¨ttingen, D-37075 Göttingen, Germany [2].</nlm:affiliation><wicri:noCountry code="subField">Germany [2]</wicri:noCountry></affiliation></author><author><name sortKey="Strohmaier, Jana" sort="Strohmaier, Jana" uniqKey="Strohmaier J" first="Jana" last="Strohmaier">Jana Strohmaier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Degenhardt, Franziska" sort="Degenhardt, Franziska" uniqKey="Degenhardt F" first="Franziska" last="Degenhardt">Franziska Degenhardt</name><affiliation wicri:level="3"><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Treutlein, Jens" sort="Treutlein, Jens" uniqKey="Treutlein J" first="Jens" last="Treutlein">Jens Treutlein</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name><affiliation wicri:level="3"><nlm:affiliation>1] Department of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark [2] Institute for Genomic Mathematics, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark [2] Institute for Genomic Mathematics, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J" last="Forstner">Andreas J. Forstner</name><affiliation wicri:level="3"><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schumacher, Johannes" sort="Schumacher, Johannes" uniqKey="Schumacher J" first="Johannes" last="Schumacher">Johannes Schumacher</name><affiliation wicri:level="3"><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Breuer, Rene" sort="Breuer, Rene" uniqKey="Breuer R" first="René" last="Breuer">René Breuer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Meier, Sandra" sort="Meier, Sandra" uniqKey="Meier S" first="Sandra" last="Meier">Sandra Meier</name><affiliation><nlm:affiliation>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim, Germany [2].</nlm:affiliation><wicri:noCountry code="subField">Germany [2]</wicri:noCountry></affiliation></author><author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name><affiliation wicri:level="1"><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel CH-4012, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel CH-4012</wicri:regionArea><wicri:noRegion>Basel CH-4012</wicri:noRegion></affiliation></author><author><name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name><affiliation wicri:level="1"><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, D-52425 Jülich, Germany [4] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel CH-4012, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, D-52425 Jülich, Germany [4] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel CH-4012</wicri:regionArea><wicri:noRegion>Basel CH-4012</wicri:noRegion></affiliation></author><author><name sortKey="Lacour, Andre" sort="Lacour, Andre" uniqKey="Lacour A" first="André" last="Lacour">André Lacour</name><affiliation wicri:level="3"><nlm:affiliation>German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, D-53175 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, D-53175 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Witt, Stephanie H" sort="Witt, Stephanie H" uniqKey="Witt S" first="Stephanie H" last="Witt">Stephanie H. Witt</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, D-97070 Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, D-97070 Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation wicri:level="1"><nlm:affiliation>1] Statistical Genetics, Department of Translational Psychiatry, Max Planck Institute of Psychiatry, D-80804 Munich, Germany [2] Munich Cluster for Systems Neurology (SyNergy), D-80336 Munich, Germany [3] Institute of Translational Medicine, University of Liverpool, L69 3BX Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1] Statistical Genetics, Department of Translational Psychiatry, Max Planck Institute of Psychiatry, D-80804 Munich, Germany [2] Munich Cluster for Systems Neurology (SyNergy), D-80336 Munich, Germany [3] Institute of Translational Medicine, University of Liverpool, L69 3BX Liverpool</wicri:regionArea><wicri:noRegion>L69 3BX Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Lucae, Susanne" sort="Lucae, Susanne" uniqKey="Lucae S" first="Susanne" last="Lucae">Susanne Lucae</name><affiliation wicri:level="3"><nlm:affiliation>Statistical Genetics, Department of Translational Psychiatry, Max Planck Institute of Psychiatry, D-80804 Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Statistical Genetics, Department of Translational Psychiatry, Max Planck Institute of Psychiatry, D-80804 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schwarz, Markus" sort="Schwarz, Markus" uniqKey="Schwarz M" first="Markus" last="Schwarz">Markus Schwarz</name><affiliation wicri:level="1"><nlm:affiliation>Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Psychiatric Center Nordbaden, D-69168 Wiesloch</wicri:regionArea><wicri:noRegion>69168 Wiesloch</wicri:noRegion><wicri:noRegion>69168 Wiesloch</wicri:noRegion><wicri:noRegion>D-69168 Wiesloch</wicri:noRegion></affiliation></author><author><name sortKey="Vedder, Helmut" sort="Vedder, Helmut" uniqKey="Vedder H" first="Helmut" last="Vedder">Helmut Vedder</name><affiliation wicri:level="1"><nlm:affiliation>Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Psychiatric Center Nordbaden, D-69168 Wiesloch</wicri:regionArea><wicri:noRegion>69168 Wiesloch</wicri:noRegion><wicri:noRegion>69168 Wiesloch</wicri:noRegion><wicri:noRegion>D-69168 Wiesloch</wicri:noRegion></affiliation></author><author><name sortKey="Kammerer Ciernioch, Jutta" sort="Kammerer Ciernioch, Jutta" uniqKey="Kammerer Ciernioch J" first="Jutta" last="Kammerer-Ciernioch">Jutta Kammerer-Ciernioch</name><affiliation wicri:level="1"><nlm:affiliation>Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Psychiatric Center Nordbaden, D-69168 Wiesloch</wicri:regionArea><wicri:noRegion>69168 Wiesloch</wicri:noRegion><wicri:noRegion>69168 Wiesloch</wicri:noRegion><wicri:noRegion>D-69168 Wiesloch</wicri:noRegion></affiliation></author><author><name sortKey="Pfennig, Andrea" sort="Pfennig, Andrea" uniqKey="Pfennig A" first="Andrea" last="Pfennig">Andrea Pfennig</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital, D-01307 Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Hospital, D-01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital, D-01307 Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Hospital, D-01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Hautzinger, Martin" sort="Hautzinger, Martin" uniqKey="Hautzinger M" first="Martin" last="Hautzinger">Martin Hautzinger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, D-72074 Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, D-72074 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, D-45147 Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, D-45147 Essen</wicri:regionArea><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>D-45147 Essen</wicri:noRegion></affiliation></author><author><name sortKey="Priebe, Lutz" sort="Priebe, Lutz" uniqKey="Priebe L" first="Lutz" last="Priebe">Lutz Priebe</name><affiliation wicri:level="3"><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M" last="Czerski">Piotr M. Czerski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Poznan University of Medical Sciences, Poznan PL-60-572, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Psychiatry, Poznan University of Medical Sciences, Poznan PL-60-572</wicri:regionArea><wicri:noRegion>Poznan PL-60-572</wicri:noRegion></affiliation></author><author><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Poznan University of Medical Sciences, Poznan PL-60-572, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Psychiatry, Poznan University of Medical Sciences, Poznan PL-60-572</wicri:regionArea><wicri:noRegion>Poznan PL-60-572</wicri:noRegion></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw PL-02-781, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw PL-02-781</wicri:regionArea><wicri:noRegion>Warsaw PL-02-781</wicri:noRegion></affiliation></author><author><name sortKey="Szeszenia Dabrowska, Neonila" sort="Szeszenia Dabrowska, Neonila" uniqKey="Szeszenia Dabrowska N" first="Neonila" last="Szeszenia-Dabrowska">Neonila Szeszenia-Dabrowska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz PL-91-348, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz PL-91-348</wicri:regionArea><wicri:noRegion>Lodz PL-91-348</wicri:noRegion></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08</wicri:regionArea><wicri:noRegion>69372 Lyon CEDEX 08</wicri:noRegion><wicri:noRegion>69372 Lyon CEDEX 08</wicri:noRegion></affiliation></author><author><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D" last="Mckay">James D. Mckay</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08</wicri:regionArea><wicri:noRegion>69372 Lyon CEDEX 08</wicri:noRegion><wicri:noRegion>69372 Lyon CEDEX 08</wicri:noRegion></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation wicri:level="1"><nlm:affiliation>1] School of Psychiatry, University of New South Wales, Randwick, New South Wales 2052, Australia [2] Black Dog Institute, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] School of Psychiatry, University of New South Wales, Randwick, New South Wales 2052, Australia [2] Black Dog Institute, Prince of Wales Hospital, Randwick, New South Wales 2031</wicri:regionArea><wicri:noRegion>New South Wales 2031</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B" last="Mitchell">Philip B. Mitchell</name><affiliation wicri:level="1"><nlm:affiliation>1] School of Psychiatry, University of New South Wales, Randwick, New South Wales 2052, Australia [2] Black Dog Institute, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] School of Psychiatry, University of New South Wales, Randwick, New South Wales 2052, Australia [2] Black Dog Institute, Prince of Wales Hospital, Randwick, New South Wales 2031</wicri:regionArea><wicri:noRegion>New South Wales 2031</wicri:noRegion></affiliation></author><author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M" last="Fullerton">Janice M. Fullerton</name><affiliation wicri:level="1"><nlm:affiliation>1] Neuroscience Research Australia, Randwick, Sydney, New South Wales 2031, Australia [2] School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] Neuroscience Research Australia, Randwick, Sydney, New South Wales 2031, Australia [2] School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2052</wicri:regionArea><wicri:noRegion>New South Wales 2052</wicri:noRegion></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name><affiliation wicri:level="1"><nlm:affiliation>1] Neuroscience Research Australia, Randwick, Sydney, New South Wales 2031, Australia [2] School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] Neuroscience Research Australia, Randwick, Sydney, New South Wales 2031, Australia [2] School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2052</wicri:regionArea><wicri:noRegion>New South Wales 2052</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E" last="Medland">Sarah E. Medland</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Gordon, Scott D" sort="Gordon, Scott D" uniqKey="Gordon S" first="Scott D" last="Gordon">Scott D. Gordon</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Krasnow, Valery" sort="Krasnow, Valery" uniqKey="Krasnow V" first="Valery" last="Krasnow">Valery Krasnow</name><affiliation wicri:level="1"><nlm:affiliation>Moscow Research Institute of Psychiatry, Moscow 107258, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Moscow Research Institute of Psychiatry, Moscow 107258</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Chuchalin, Alexander" sort="Chuchalin, Alexander" uniqKey="Chuchalin A" first="Alexander" last="Chuchalin">Alexander Chuchalin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pulmonology, Russian State Medical University, Moscow 105077, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Pulmonology, Russian State Medical University, Moscow 105077</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Babadjanova, Gulja" sort="Babadjanova, Gulja" uniqKey="Babadjanova G" first="Gulja" last="Babadjanova">Gulja Babadjanova</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pulmonology, Russian State Medical University, Moscow 105077, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Pulmonology, Russian State Medical University, Moscow 105077</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Pantelejeva, Galina" sort="Pantelejeva, Galina" uniqKey="Pantelejeva G" first="Galina" last="Pantelejeva">Galina Pantelejeva</name><affiliation wicri:level="1"><nlm:affiliation>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow 115522, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow 115522</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Abramova, Lilia I" sort="Abramova, Lilia I" uniqKey="Abramova L" first="Lilia I" last="Abramova">Lilia I. Abramova</name><affiliation wicri:level="1"><nlm:affiliation>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow 115522, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow 115522</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Tiganov, Alexander S" sort="Tiganov, Alexander S" uniqKey="Tiganov A" first="Alexander S" last="Tiganov">Alexander S. Tiganov</name><affiliation wicri:level="1"><nlm:affiliation>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow 115522, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow 115522</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Polonikov, Alexey" sort="Polonikov, Alexey" uniqKey="Polonikov A" first="Alexey" last="Polonikov">Alexey Polonikov</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk 305041, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk 305041</wicri:regionArea><wicri:noRegion>Kursk 305041</wicri:noRegion></affiliation></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa 450054, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa 450054</wicri:regionArea><wicri:noRegion>Ufa 450054</wicri:noRegion></affiliation></author><author><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name><affiliation wicri:level="3"><nlm:affiliation>1] Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 2E2 [2] The International Group for the Study of Lithium-Treated Patients (IGSLI), Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 2E2 [2] The International Group for the Study of Lithium-Treated Patients (IGSLI), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Grof, Paul" sort="Grof, Paul" uniqKey="Grof P" first="Paul" last="Grof">Paul Grof</name><affiliation wicri:level="4"><nlm:affiliation>1] The International Group for the Study of Lithium-Treated Patients (IGSLI), Berlin, Germany [2] Mood Disorders Center of Ottawa, Ottawa, Ontario, Canada K1G 4G3 [3] Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada M5T 1R8.</nlm:affiliation><country>Canada</country><wicri:regionArea>1] The International Group for the Study of Lithium-Treated Patients (IGSLI), Berlin, Germany [2] Mood Disorders Center of Ottawa, Ottawa, Ontario, Canada K1G 4G3 [3] Department of Psychiatry, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, McGill University, Montreal, Québec, Canada H3G 1A4.</nlm:affiliation><country>Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, McGill University, Montreal, Québec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Douglas Hospital Research Institute, McGill University, Montreal, Quebec, Canada H4H 1R3.</nlm:affiliation><country>Canada</country><wicri:regionArea>Department of Psychiatry, Douglas Hospital Research Institute, McGill University, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Laprise, Catherine" sort="Laprise, Catherine" uniqKey="Laprise C" first="Catherine" last="Laprise">Catherine Laprise</name><affiliation wicri:level="1"><nlm:affiliation>Département des sciences fondamentales, Université du Québec à Chicoutimi (UQAC), Saguenay, Canada G7H 2B1.</nlm:affiliation><country>Canada</country><wicri:regionArea>Département des sciences fondamentales, Université du Québec à Chicoutimi (UQAC), Saguenay</wicri:regionArea><wicri:noRegion>Saguenay</wicri:noRegion></affiliation></author><author><name sortKey="Rivas, Fabio" sort="Rivas, Fabio" uniqKey="Rivas F" first="Fabio" last="Rivas">Fabio Rivas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Hospital Regional Universitario Carlos Haya, Malaga 29009, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry, Hospital Regional Universitario Carlos Haya, Malaga 29009</wicri:regionArea><wicri:noRegion>Malaga 29009</wicri:noRegion></affiliation></author><author><name sortKey="Mayoral, Fermin" sort="Mayoral, Fermin" uniqKey="Mayoral F" first="Fermin" last="Mayoral">Fermin Mayoral</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Hospital Regional Universitario Carlos Haya, Malaga 29009, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry, Hospital Regional Universitario Carlos Haya, Malaga 29009</wicri:regionArea><wicri:noRegion>Malaga 29009</wicri:noRegion></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation wicri:level="1"><nlm:affiliation>Center for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Research in Environmental Epidemiology (CREAL), Barcelona 08003</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name><affiliation wicri:level="1"><nlm:affiliation>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest RO-041914, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest RO-041914</wicri:regionArea><wicri:noRegion>Bucharest RO-041914</wicri:noRegion></affiliation></author><author><name sortKey="Propping, Peter" sort="Propping, Peter" uniqKey="Propping P" first="Peter" last="Propping">Peter Propping</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name><affiliation wicri:level="3"><nlm:affiliation>1] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, D-53175 Bonn, Germany [2] Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, D-53175 Bonn, Germany [2] Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><affiliation><nlm:affiliation>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim, Germany [2].</nlm:affiliation><wicri:noCountry code="subField">Germany [2]</wicri:noCountry></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3].</nlm:affiliation><wicri:noCountry code="subField">Germany [3]</wicri:noCountry></affiliation></author><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, D-52425 Jülich, Germany [4] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel CH-4012, Switzerland [5].</nlm:affiliation><wicri:noCountry code="subField">Switzerland [5]</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24618891</idno><idno type="pmid">24618891</idno><idno type="doi">10.1038/ncomms4339</idno><idno type="wicri:Area/PubMed/Corpus">003878</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">003878</idno><idno type="wicri:Area/PubMed/Curation">003763</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">003763</idno><idno type="wicri:Area/PubMed/Checkpoint">003763</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">003763</idno><idno type="wicri:Area/Ncbi/Merge">001856</idno><idno type="wicri:Area/Ncbi/Curation">001856</idno><idno type="wicri:Area/Ncbi/Checkpoint">001856</idno><idno type="wicri:Area/Main/Merge">003942</idno><idno type="wicri:Area/Main/Curation">003906</idno><idno type="wicri:Area/Main/Exploration">003906</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Genome-wide association study reveals two new risk loci for bipolar disorder.</title><author><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W" last="Mühleisen">Thomas W. Mühleisen</name><affiliation><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, D-52425 Jülich, Germany [4].</nlm:affiliation><wicri:noCountry code="subField">Germany [4]</wicri:noCountry></affiliation></author><author><name sortKey="Leber, Markus" sort="Leber, Markus" uniqKey="Leber M" first="Markus" last="Leber">Markus Leber</name><affiliation><nlm:affiliation>1] Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany [2] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, D-53175 Bonn, Germany [3].</nlm:affiliation><wicri:noCountry code="subField">Germany [3]</wicri:noCountry></affiliation></author><author><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G" last="Schulze">Thomas G. Schulze</name><affiliation><nlm:affiliation>1] Department of Psychiatry and Psychotherapy, University of Go¨ttingen, D-37075 Göttingen, Germany [2].</nlm:affiliation><wicri:noCountry code="subField">Germany [2]</wicri:noCountry></affiliation></author><author><name sortKey="Strohmaier, Jana" sort="Strohmaier, Jana" uniqKey="Strohmaier J" first="Jana" last="Strohmaier">Jana Strohmaier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Degenhardt, Franziska" sort="Degenhardt, Franziska" uniqKey="Degenhardt F" first="Franziska" last="Degenhardt">Franziska Degenhardt</name><affiliation wicri:level="3"><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Treutlein, Jens" sort="Treutlein, Jens" uniqKey="Treutlein J" first="Jens" last="Treutlein">Jens Treutlein</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name><affiliation wicri:level="3"><nlm:affiliation>1] Department of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark [2] Institute for Genomic Mathematics, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Biomedicine, Aarhus University, DK-8000 Aarhus C, Denmark [2] Institute for Genomic Mathematics, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J" last="Forstner">Andreas J. Forstner</name><affiliation wicri:level="3"><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schumacher, Johannes" sort="Schumacher, Johannes" uniqKey="Schumacher J" first="Johannes" last="Schumacher">Johannes Schumacher</name><affiliation wicri:level="3"><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Breuer, Rene" sort="Breuer, Rene" uniqKey="Breuer R" first="René" last="Breuer">René Breuer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Meier, Sandra" sort="Meier, Sandra" uniqKey="Meier S" first="Sandra" last="Meier">Sandra Meier</name><affiliation><nlm:affiliation>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim, Germany [2].</nlm:affiliation><wicri:noCountry code="subField">Germany [2]</wicri:noCountry></affiliation></author><author><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name><affiliation wicri:level="1"><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel CH-4012, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel CH-4012</wicri:regionArea><wicri:noRegion>Basel CH-4012</wicri:noRegion></affiliation></author><author><name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name><affiliation wicri:level="1"><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, D-52425 Jülich, Germany [4] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel CH-4012, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, D-52425 Jülich, Germany [4] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel CH-4012</wicri:regionArea><wicri:noRegion>Basel CH-4012</wicri:noRegion></affiliation></author><author><name sortKey="Lacour, Andre" sort="Lacour, Andre" uniqKey="Lacour A" first="André" last="Lacour">André Lacour</name><affiliation wicri:level="3"><nlm:affiliation>German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, D-53175 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, D-53175 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Witt, Stephanie H" sort="Witt, Stephanie H" uniqKey="Witt S" first="Stephanie H" last="Witt">Stephanie H. Witt</name><affiliation wicri:level="3"><nlm:affiliation>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Mannheim</settlement></placeName></affiliation></author><author><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, D-97070 Würzburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, D-97070 Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name><affiliation wicri:level="1"><nlm:affiliation>1] Statistical Genetics, Department of Translational Psychiatry, Max Planck Institute of Psychiatry, D-80804 Munich, Germany [2] Munich Cluster for Systems Neurology (SyNergy), D-80336 Munich, Germany [3] Institute of Translational Medicine, University of Liverpool, L69 3BX Liverpool, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>1] Statistical Genetics, Department of Translational Psychiatry, Max Planck Institute of Psychiatry, D-80804 Munich, Germany [2] Munich Cluster for Systems Neurology (SyNergy), D-80336 Munich, Germany [3] Institute of Translational Medicine, University of Liverpool, L69 3BX Liverpool</wicri:regionArea><wicri:noRegion>L69 3BX Liverpool</wicri:noRegion></affiliation></author><author><name sortKey="Lucae, Susanne" sort="Lucae, Susanne" uniqKey="Lucae S" first="Susanne" last="Lucae">Susanne Lucae</name><affiliation wicri:level="3"><nlm:affiliation>Statistical Genetics, Department of Translational Psychiatry, Max Planck Institute of Psychiatry, D-80804 Munich, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Statistical Genetics, Department of Translational Psychiatry, Max Planck Institute of Psychiatry, D-80804 Munich</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Schwarz, Markus" sort="Schwarz, Markus" uniqKey="Schwarz M" first="Markus" last="Schwarz">Markus Schwarz</name><affiliation wicri:level="1"><nlm:affiliation>Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Psychiatric Center Nordbaden, D-69168 Wiesloch</wicri:regionArea><wicri:noRegion>69168 Wiesloch</wicri:noRegion><wicri:noRegion>69168 Wiesloch</wicri:noRegion><wicri:noRegion>D-69168 Wiesloch</wicri:noRegion></affiliation></author><author><name sortKey="Vedder, Helmut" sort="Vedder, Helmut" uniqKey="Vedder H" first="Helmut" last="Vedder">Helmut Vedder</name><affiliation wicri:level="1"><nlm:affiliation>Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Psychiatric Center Nordbaden, D-69168 Wiesloch</wicri:regionArea><wicri:noRegion>69168 Wiesloch</wicri:noRegion><wicri:noRegion>69168 Wiesloch</wicri:noRegion><wicri:noRegion>D-69168 Wiesloch</wicri:noRegion></affiliation></author><author><name sortKey="Kammerer Ciernioch, Jutta" sort="Kammerer Ciernioch, Jutta" uniqKey="Kammerer Ciernioch J" first="Jutta" last="Kammerer-Ciernioch">Jutta Kammerer-Ciernioch</name><affiliation wicri:level="1"><nlm:affiliation>Psychiatric Center Nordbaden, D-69168 Wiesloch, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Psychiatric Center Nordbaden, D-69168 Wiesloch</wicri:regionArea><wicri:noRegion>69168 Wiesloch</wicri:noRegion><wicri:noRegion>69168 Wiesloch</wicri:noRegion><wicri:noRegion>D-69168 Wiesloch</wicri:noRegion></affiliation></author><author><name sortKey="Pfennig, Andrea" sort="Pfennig, Andrea" uniqKey="Pfennig A" first="Andrea" last="Pfennig">Andrea Pfennig</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital, D-01307 Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Hospital, D-01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry and Psychotherapy, University Hospital, D-01307 Dresden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry and Psychotherapy, University Hospital, D-01307 Dresden</wicri:regionArea><placeName><region type="land" nuts="1">Saxe (Land)</region><region type="district" nuts="2">District de Dresde</region><settlement type="city">Dresde</settlement></placeName></affiliation></author><author><name sortKey="Hautzinger, Martin" sort="Hautzinger, Martin" uniqKey="Hautzinger M" first="Martin" last="Hautzinger">Martin Hautzinger</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, D-72074 Tübingen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychology, Clinical Psychology and Psychotherapy, Eberhard Karls University Tübingen, D-72074 Tübingen</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Tübingen</region><settlement type="city">Tübingen</settlement></placeName></affiliation></author><author><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, D-45147 Essen, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Informatics, Biometry, and Epidemiology, University Duisburg-Essen, D-45147 Essen</wicri:regionArea><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>45147 Essen</wicri:noRegion><wicri:noRegion>D-45147 Essen</wicri:noRegion></affiliation></author><author><name sortKey="Priebe, Lutz" sort="Priebe, Lutz" uniqKey="Priebe L" first="Lutz" last="Priebe">Lutz Priebe</name><affiliation wicri:level="3"><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M" last="Czerski">Piotr M. Czerski</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Poznan University of Medical Sciences, Poznan PL-60-572, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Psychiatry, Poznan University of Medical Sciences, Poznan PL-60-572</wicri:regionArea><wicri:noRegion>Poznan PL-60-572</wicri:noRegion></affiliation></author><author><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Poznan University of Medical Sciences, Poznan PL-60-572, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Psychiatry, Poznan University of Medical Sciences, Poznan PL-60-572</wicri:regionArea><wicri:noRegion>Poznan PL-60-572</wicri:noRegion></affiliation></author><author><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw PL-02-781, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Cancer Epidemiology and Prevention, Maria Sklodowska-Curie Memorial Cancer Centre and Institute of Oncology, Warsaw PL-02-781</wicri:regionArea><wicri:noRegion>Warsaw PL-02-781</wicri:noRegion></affiliation></author><author><name sortKey="Szeszenia Dabrowska, Neonila" sort="Szeszenia Dabrowska, Neonila" uniqKey="Szeszenia Dabrowska N" first="Neonila" last="Szeszenia-Dabrowska">Neonila Szeszenia-Dabrowska</name><affiliation wicri:level="1"><nlm:affiliation>Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz PL-91-348, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Department of Epidemiology, Nofer Institute of Occupational Medicine, Lodz PL-91-348</wicri:regionArea><wicri:noRegion>Lodz PL-91-348</wicri:noRegion></affiliation></author><author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Genetic Epidemiology Group, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08</wicri:regionArea><wicri:noRegion>69372 Lyon CEDEX 08</wicri:noRegion><wicri:noRegion>69372 Lyon CEDEX 08</wicri:noRegion></affiliation></author><author><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D" last="Mckay">James D. Mckay</name><affiliation wicri:level="1"><nlm:affiliation>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Genetic Cancer Susceptibility Group, International Agency for Research on Cancer (IARC), 69372 Lyon CEDEX 08</wicri:regionArea><wicri:noRegion>69372 Lyon CEDEX 08</wicri:noRegion><wicri:noRegion>69372 Lyon CEDEX 08</wicri:noRegion></affiliation></author><author><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name><affiliation wicri:level="1"><nlm:affiliation>1] School of Psychiatry, University of New South Wales, Randwick, New South Wales 2052, Australia [2] Black Dog Institute, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] School of Psychiatry, University of New South Wales, Randwick, New South Wales 2052, Australia [2] Black Dog Institute, Prince of Wales Hospital, Randwick, New South Wales 2031</wicri:regionArea><wicri:noRegion>New South Wales 2031</wicri:noRegion></affiliation></author><author><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B" last="Mitchell">Philip B. Mitchell</name><affiliation wicri:level="1"><nlm:affiliation>1] School of Psychiatry, University of New South Wales, Randwick, New South Wales 2052, Australia [2] Black Dog Institute, Prince of Wales Hospital, Randwick, New South Wales 2031, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] School of Psychiatry, University of New South Wales, Randwick, New South Wales 2052, Australia [2] Black Dog Institute, Prince of Wales Hospital, Randwick, New South Wales 2031</wicri:regionArea><wicri:noRegion>New South Wales 2031</wicri:noRegion></affiliation></author><author><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M" last="Fullerton">Janice M. Fullerton</name><affiliation wicri:level="1"><nlm:affiliation>1] Neuroscience Research Australia, Randwick, Sydney, New South Wales 2031, Australia [2] School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] Neuroscience Research Australia, Randwick, Sydney, New South Wales 2031, Australia [2] School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2052</wicri:regionArea><wicri:noRegion>New South Wales 2052</wicri:noRegion></affiliation></author><author><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name><affiliation wicri:level="1"><nlm:affiliation>1] Neuroscience Research Australia, Randwick, Sydney, New South Wales 2031, Australia [2] School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2052, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>1] Neuroscience Research Australia, Randwick, Sydney, New South Wales 2031, Australia [2] School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, New South Wales 2052</wicri:regionArea><wicri:noRegion>New South Wales 2052</wicri:noRegion></affiliation></author><author><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E" last="Medland">Sarah E. Medland</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Gordon, Scott D" sort="Gordon, Scott D" uniqKey="Gordon S" first="Scott D" last="Gordon">Scott D. Gordon</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><affiliation wicri:level="1"><nlm:affiliation>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Queensland Institute of Medical Research (QIMR), Brisbane, Queensland 4006</wicri:regionArea><wicri:noRegion>Queensland 4006</wicri:noRegion></affiliation></author><author><name sortKey="Krasnow, Valery" sort="Krasnow, Valery" uniqKey="Krasnow V" first="Valery" last="Krasnow">Valery Krasnow</name><affiliation wicri:level="1"><nlm:affiliation>Moscow Research Institute of Psychiatry, Moscow 107258, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Moscow Research Institute of Psychiatry, Moscow 107258</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Chuchalin, Alexander" sort="Chuchalin, Alexander" uniqKey="Chuchalin A" first="Alexander" last="Chuchalin">Alexander Chuchalin</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pulmonology, Russian State Medical University, Moscow 105077, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Pulmonology, Russian State Medical University, Moscow 105077</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Babadjanova, Gulja" sort="Babadjanova, Gulja" uniqKey="Babadjanova G" first="Gulja" last="Babadjanova">Gulja Babadjanova</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pulmonology, Russian State Medical University, Moscow 105077, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Pulmonology, Russian State Medical University, Moscow 105077</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Pantelejeva, Galina" sort="Pantelejeva, Galina" uniqKey="Pantelejeva G" first="Galina" last="Pantelejeva">Galina Pantelejeva</name><affiliation wicri:level="1"><nlm:affiliation>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow 115522, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow 115522</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Abramova, Lilia I" sort="Abramova, Lilia I" uniqKey="Abramova L" first="Lilia I" last="Abramova">Lilia I. Abramova</name><affiliation wicri:level="1"><nlm:affiliation>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow 115522, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow 115522</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Tiganov, Alexander S" sort="Tiganov, Alexander S" uniqKey="Tiganov A" first="Alexander S" last="Tiganov">Alexander S. Tiganov</name><affiliation wicri:level="1"><nlm:affiliation>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow 115522, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Russian Academy of Medical Sciences, Mental Health Research Center, Moscow 115522</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Polonikov, Alexey" sort="Polonikov, Alexey" uniqKey="Polonikov A" first="Alexey" last="Polonikov">Alexey Polonikov</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk 305041, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Biology, Medical Genetics and Ecology, Kursk State Medical University, Kursk 305041</wicri:regionArea><wicri:noRegion>Kursk 305041</wicri:noRegion></affiliation></author><author><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa 450054, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa 450054</wicri:regionArea><wicri:noRegion>Ufa 450054</wicri:noRegion></affiliation></author><author><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name><affiliation wicri:level="3"><nlm:affiliation>1] Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 2E2 [2] The International Group for the Study of Lithium-Treated Patients (IGSLI), Berlin, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 2E2 [2] The International Group for the Study of Lithium-Treated Patients (IGSLI), Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Grof, Paul" sort="Grof, Paul" uniqKey="Grof P" first="Paul" last="Grof">Paul Grof</name><affiliation wicri:level="4"><nlm:affiliation>1] The International Group for the Study of Lithium-Treated Patients (IGSLI), Berlin, Germany [2] Mood Disorders Center of Ottawa, Ottawa, Ontario, Canada K1G 4G3 [3] Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada M5T 1R8.</nlm:affiliation><country>Canada</country><wicri:regionArea>1] The International Group for the Study of Lithium-Treated Patients (IGSLI), Berlin, Germany [2] Mood Disorders Center of Ottawa, Ottawa, Ontario, Canada K1G 4G3 [3] Department of Psychiatry, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, McGill University, Montreal, Québec, Canada H3G 1A4.</nlm:affiliation><country>Canada</country><wicri:regionArea>Department of Neurology and Neurosurgery, Montreal Neurological Hospital and Institute, McGill University, Montreal, Québec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychiatry, Douglas Hospital Research Institute, McGill University, Montreal, Quebec, Canada H4H 1R3.</nlm:affiliation><country>Canada</country><wicri:regionArea>Department of Psychiatry, Douglas Hospital Research Institute, McGill University, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Laprise, Catherine" sort="Laprise, Catherine" uniqKey="Laprise C" first="Catherine" last="Laprise">Catherine Laprise</name><affiliation wicri:level="1"><nlm:affiliation>Département des sciences fondamentales, Université du Québec à Chicoutimi (UQAC), Saguenay, Canada G7H 2B1.</nlm:affiliation><country>Canada</country><wicri:regionArea>Département des sciences fondamentales, Université du Québec à Chicoutimi (UQAC), Saguenay</wicri:regionArea><wicri:noRegion>Saguenay</wicri:noRegion></affiliation></author><author><name sortKey="Rivas, Fabio" sort="Rivas, Fabio" uniqKey="Rivas F" first="Fabio" last="Rivas">Fabio Rivas</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Hospital Regional Universitario Carlos Haya, Malaga 29009, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry, Hospital Regional Universitario Carlos Haya, Malaga 29009</wicri:regionArea><wicri:noRegion>Malaga 29009</wicri:noRegion></affiliation></author><author><name sortKey="Mayoral, Fermin" sort="Mayoral, Fermin" uniqKey="Mayoral F" first="Fermin" last="Mayoral">Fermin Mayoral</name><affiliation wicri:level="1"><nlm:affiliation>Department of Psychiatry, Hospital Regional Universitario Carlos Haya, Malaga 29009, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Psychiatry, Hospital Regional Universitario Carlos Haya, Malaga 29009</wicri:regionArea><wicri:noRegion>Malaga 29009</wicri:noRegion></affiliation></author><author><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><affiliation wicri:level="1"><nlm:affiliation>Center for Research in Environmental Epidemiology (CREAL), Barcelona 08003, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Center for Research in Environmental Epidemiology (CREAL), Barcelona 08003</wicri:regionArea><placeName><settlement type="city">Barcelone</settlement><region nuts="2" type="region">Catalogne</region></placeName></affiliation></author><author><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name><affiliation wicri:level="1"><nlm:affiliation>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest RO-041914, Romania.</nlm:affiliation><country xml:lang="fr">Roumanie</country><wicri:regionArea>Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest RO-041914</wicri:regionArea><wicri:noRegion>Bucharest RO-041914</wicri:noRegion></affiliation></author><author><name sortKey="Propping, Peter" sort="Propping, Peter" uniqKey="Propping P" first="Peter" last="Propping">Peter Propping</name><affiliation wicri:level="3"><nlm:affiliation>Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name><affiliation wicri:level="3"><nlm:affiliation>1] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, D-53175 Bonn, Germany [2] Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>1] German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany, D-53175 Bonn, Germany [2] Institute for Medical Biometry, Informatics, and Epidemiology, University of Bonn, D-53127 Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><affiliation><nlm:affiliation>1] Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, D-68159 Mannheim, Germany [2].</nlm:affiliation><wicri:noCountry code="subField">Germany [2]</wicri:noCountry></affiliation></author><author><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><affiliation><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3].</nlm:affiliation><wicri:noCountry code="subField">Germany [3]</wicri:noCountry></affiliation></author><author><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><affiliation><nlm:affiliation>1] Institute of Human Genetics, University of Bonn, D-53127 Bonn, Germany [2] Department of Genomics, Life & Brain Center, University of Bonn, D-53127 Bonn, Germany [3] Institute of Neuroscience and Medicine (INM-1), Research Centre Jülich, D-52425 Jülich, Germany [4] Division of Medical Genetics, Department of Biomedicine, University of Basel, Basel CH-4012, Switzerland [5].</nlm:affiliation><wicri:noCountry code="subField">Switzerland [5]</wicri:noCountry></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adenylyl Cyclases (genetics)</term><term>Bipolar Disorder (genetics)</term><term>Female</term><term>Genetic Predisposition to Disease (genetics)</term><term>Genome-Wide Association Study (methods)</term><term>Humans</term><term>Male</term><term>Polymorphism, Single Nucleotide (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adenylate Cyclase (génétique)</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Polymorphisme de nucléotide simple (génétique)</term><term>Prédisposition génétique à une maladie (génétique)</term><term>Trouble bipolaire (génétique)</term><term>Étude d'association pangénomique ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Adenylyl Cyclases</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Bipolar Disorder</term><term>Genetic Predisposition to Disease</term><term>Polymorphism, Single Nucleotide</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Adenylate Cyclase</term><term>Polymorphisme de nucléotide simple</term><term>Prédisposition génétique à une maladie</term><term>Trouble bipolaire</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Genome-Wide Association Study</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Female</term><term>Humans</term><term>Male</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Étude d'association pangénomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Pologne</li><li>Roumanie</li><li>Royaume-Uni</li><li>Russie</li><li>Suisse</li></country><region><li>Bade-Wurtemberg</li><li>Bavière</li><li>Berlin</li><li>Catalogne</li><li>District de Basse-Franconie</li><li>District de Cologne</li><li>District de Dresde</li><li>District de Haute-Bavière</li><li>District de Karlsruhe</li><li>District de Tübingen</li><li>District fédéral central</li><li>Ontario</li><li>Québec</li><li>Rhénanie-du-Nord-Westphalie</li><li>Saxe (Land)</li></region><settlement><li>Barcelone</li><li>Berlin</li><li>Bonn</li><li>Dresde</li><li>Mannheim</li><li>Montréal</li><li>Moscou</li><li>Munich</li><li>Toronto</li><li>Tübingen</li><li>Wurtzbourg</li></settlement><orgName><li>Université McGill</li><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Cichon, Sven" sort="Cichon, Sven" uniqKey="Cichon S" first="Sven" last="Cichon">Sven Cichon</name><name sortKey="Leber, Markus" sort="Leber, Markus" uniqKey="Leber M" first="Markus" last="Leber">Markus Leber</name><name sortKey="Meier, Sandra" sort="Meier, Sandra" uniqKey="Meier S" first="Sandra" last="Meier">Sandra Meier</name><name sortKey="Muhleisen, Thomas W" sort="Muhleisen, Thomas W" uniqKey="Muhleisen T" first="Thomas W" last="Mühleisen">Thomas W. Mühleisen</name><name sortKey="Nothen, Markus M" sort="Nothen, Markus M" uniqKey="Nothen M" first="Markus M" last="Nöthen">Markus M. Nöthen</name><name sortKey="Rietschel, Marcella" sort="Rietschel, Marcella" uniqKey="Rietschel M" first="Marcella" last="Rietschel">Marcella Rietschel</name><name sortKey="Schulze, Thomas G" sort="Schulze, Thomas G" uniqKey="Schulze T" first="Thomas G" last="Schulze">Thomas G. Schulze</name></noCountry><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Strohmaier, Jana" sort="Strohmaier, Jana" uniqKey="Strohmaier J" first="Jana" last="Strohmaier">Jana Strohmaier</name></region><name sortKey="Alda, Martin" sort="Alda, Martin" uniqKey="Alda M" first="Martin" last="Alda">Martin Alda</name><name sortKey="Bauer, Michael" sort="Bauer, Michael" uniqKey="Bauer M" first="Michael" last="Bauer">Michael Bauer</name><name sortKey="Becker, Tim" sort="Becker, Tim" uniqKey="Becker T" first="Tim" last="Becker">Tim Becker</name><name sortKey="Breuer, Rene" sort="Breuer, Rene" uniqKey="Breuer R" first="René" last="Breuer">René Breuer</name><name sortKey="Degenhardt, Franziska" sort="Degenhardt, Franziska" uniqKey="Degenhardt F" first="Franziska" last="Degenhardt">Franziska Degenhardt</name><name sortKey="Forstner, Andreas J" sort="Forstner, Andreas J" uniqKey="Forstner A" first="Andreas J" last="Forstner">Andreas J. Forstner</name><name sortKey="Hautzinger, Martin" sort="Hautzinger, Martin" uniqKey="Hautzinger M" first="Martin" last="Hautzinger">Martin Hautzinger</name><name sortKey="Kammerer Ciernioch, Jutta" sort="Kammerer Ciernioch, Jutta" uniqKey="Kammerer Ciernioch J" first="Jutta" last="Kammerer-Ciernioch">Jutta Kammerer-Ciernioch</name><name sortKey="Lacour, Andre" sort="Lacour, Andre" uniqKey="Lacour A" first="André" last="Lacour">André Lacour</name><name sortKey="Lucae, Susanne" sort="Lucae, Susanne" uniqKey="Lucae S" first="Susanne" last="Lucae">Susanne Lucae</name><name sortKey="Maier, Wolfgang" sort="Maier, Wolfgang" uniqKey="Maier W" first="Wolfgang" last="Maier">Wolfgang Maier</name><name sortKey="Mattheisen, Manuel" sort="Mattheisen, Manuel" uniqKey="Mattheisen M" first="Manuel" last="Mattheisen">Manuel Mattheisen</name><name sortKey="Moebus, Susanne" sort="Moebus, Susanne" uniqKey="Moebus S" first="Susanne" last="Moebus">Susanne Moebus</name><name sortKey="Pfennig, Andrea" sort="Pfennig, Andrea" uniqKey="Pfennig A" first="Andrea" last="Pfennig">Andrea Pfennig</name><name sortKey="Priebe, Lutz" sort="Priebe, Lutz" uniqKey="Priebe L" first="Lutz" last="Priebe">Lutz Priebe</name><name sortKey="Propping, Peter" sort="Propping, Peter" uniqKey="Propping P" first="Peter" last="Propping">Peter Propping</name><name sortKey="Reif, Andreas" sort="Reif, Andreas" uniqKey="Reif A" first="Andreas" last="Reif">Andreas Reif</name><name sortKey="Schumacher, Johannes" sort="Schumacher, Johannes" uniqKey="Schumacher J" first="Johannes" last="Schumacher">Johannes Schumacher</name><name sortKey="Schwarz, Markus" sort="Schwarz, Markus" uniqKey="Schwarz M" first="Markus" last="Schwarz">Markus Schwarz</name><name sortKey="Treutlein, Jens" sort="Treutlein, Jens" uniqKey="Treutlein J" first="Jens" last="Treutlein">Jens Treutlein</name><name sortKey="Vedder, Helmut" sort="Vedder, Helmut" uniqKey="Vedder H" first="Helmut" last="Vedder">Helmut Vedder</name><name sortKey="Witt, Stephanie H" sort="Witt, Stephanie H" uniqKey="Witt S" first="Stephanie H" last="Witt">Stephanie H. Witt</name></country><country name="Suisse"><noRegion><name sortKey="Herms, Stefan" sort="Herms, Stefan" uniqKey="Herms S" first="Stefan" last="Herms">Stefan Herms</name></noRegion><name sortKey="Hoffmann, Per" sort="Hoffmann, Per" uniqKey="Hoffmann P" first="Per" last="Hoffmann">Per Hoffmann</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name></noRegion></country><country name="Pologne"><noRegion><name sortKey="Czerski, Piotr M" sort="Czerski, Piotr M" uniqKey="Czerski P" first="Piotr M" last="Czerski">Piotr M. Czerski</name></noRegion><name sortKey="Hauser, Joanna" sort="Hauser, Joanna" uniqKey="Hauser J" first="Joanna" last="Hauser">Joanna Hauser</name><name sortKey="Lissowska, Jolanta" sort="Lissowska, Jolanta" uniqKey="Lissowska J" first="Jolanta" last="Lissowska">Jolanta Lissowska</name><name sortKey="Szeszenia Dabrowska, Neonila" sort="Szeszenia Dabrowska, Neonila" uniqKey="Szeszenia Dabrowska N" first="Neonila" last="Szeszenia-Dabrowska">Neonila Szeszenia-Dabrowska</name></country><country name="France"><noRegion><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name></noRegion><name sortKey="Mckay, James D" sort="Mckay, James D" uniqKey="Mckay J" first="James D" last="Mckay">James D. Mckay</name></country><country name="Australie"><noRegion><name sortKey="Wright, Adam" sort="Wright, Adam" uniqKey="Wright A" first="Adam" last="Wright">Adam Wright</name></noRegion><name sortKey="Fullerton, Janice M" sort="Fullerton, Janice M" uniqKey="Fullerton J" first="Janice M" last="Fullerton">Janice M. Fullerton</name><name sortKey="Gordon, Scott D" sort="Gordon, Scott D" uniqKey="Gordon S" first="Scott D" last="Gordon">Scott D. Gordon</name><name sortKey="Martin, Nicholas G" sort="Martin, Nicholas G" uniqKey="Martin N" first="Nicholas G" last="Martin">Nicholas G. Martin</name><name sortKey="Medland, Sarah E" sort="Medland, Sarah E" uniqKey="Medland S" first="Sarah E" last="Medland">Sarah E. Medland</name><name sortKey="Mitchell, Philip B" sort="Mitchell, Philip B" uniqKey="Mitchell P" first="Philip B" last="Mitchell">Philip B. Mitchell</name><name sortKey="Montgomery, Grant W" sort="Montgomery, Grant W" uniqKey="Montgomery G" first="Grant W" last="Montgomery">Grant W. Montgomery</name><name sortKey="Schofield, Peter R" sort="Schofield, Peter R" uniqKey="Schofield P" first="Peter R" last="Schofield">Peter R. Schofield</name></country><country name="Russie"><region name="District fédéral central"><name sortKey="Krasnow, Valery" sort="Krasnow, Valery" uniqKey="Krasnow V" first="Valery" last="Krasnow">Valery Krasnow</name></region><name sortKey="Abramova, Lilia I" sort="Abramova, Lilia I" uniqKey="Abramova L" first="Lilia I" last="Abramova">Lilia I. Abramova</name><name sortKey="Babadjanova, Gulja" sort="Babadjanova, Gulja" uniqKey="Babadjanova G" first="Gulja" last="Babadjanova">Gulja Babadjanova</name><name sortKey="Chuchalin, Alexander" sort="Chuchalin, Alexander" uniqKey="Chuchalin A" first="Alexander" last="Chuchalin">Alexander Chuchalin</name><name sortKey="Khusnutdinova, Elza" sort="Khusnutdinova, Elza" uniqKey="Khusnutdinova E" first="Elza" last="Khusnutdinova">Elza Khusnutdinova</name><name sortKey="Pantelejeva, Galina" sort="Pantelejeva, Galina" uniqKey="Pantelejeva G" first="Galina" last="Pantelejeva">Galina Pantelejeva</name><name sortKey="Polonikov, Alexey" sort="Polonikov, Alexey" uniqKey="Polonikov A" first="Alexey" last="Polonikov">Alexey Polonikov</name><name sortKey="Tiganov, Alexander S" sort="Tiganov, Alexander S" uniqKey="Tiganov A" first="Alexander S" last="Tiganov">Alexander S. Tiganov</name></country><country name="Canada"><region name="Ontario"><name sortKey="Grof, Paul" sort="Grof, Paul" uniqKey="Grof P" first="Paul" last="Grof">Paul Grof</name></region><name sortKey="Laprise, Catherine" sort="Laprise, Catherine" uniqKey="Laprise C" first="Catherine" last="Laprise">Catherine Laprise</name><name sortKey="Rouleau, Guy A" sort="Rouleau, Guy A" uniqKey="Rouleau G" first="Guy A" last="Rouleau">Guy A. Rouleau</name><name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name></country><country name="Espagne"><noRegion><name sortKey="Rivas, Fabio" sort="Rivas, Fabio" uniqKey="Rivas F" first="Fabio" last="Rivas">Fabio Rivas</name></noRegion><name sortKey="Kogevinas, Manolis" sort="Kogevinas, Manolis" uniqKey="Kogevinas M" first="Manolis" last="Kogevinas">Manolis Kogevinas</name><name sortKey="Mayoral, Fermin" sort="Mayoral, Fermin" uniqKey="Mayoral F" first="Fermin" last="Mayoral">Fermin Mayoral</name></country><country name="Roumanie"><noRegion><name sortKey="Grigoroiu Serbanescu, Maria" sort="Grigoroiu Serbanescu, Maria" uniqKey="Grigoroiu Serbanescu M" first="Maria" last="Grigoroiu-Serbanescu">Maria Grigoroiu-Serbanescu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Genome-wide association study reveals two new risk loci for bipolar disorder.
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